Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease.

Celiac disease (CD) is a malabsorptive disorder of the small intestine. The disease is a unique model for studies of HLA-associated diseases since (a) the disease shows a stringent HLA association; (b) the disease-inducing agent (wheat gluten and related antigens from other cereals) is known; (c) activated, gluten-specific CD4 + T cells in the lamina propria of the small intestine most likely play an important immunopathogenic role; and (d) the target organ is accessible for obtaining biopsy specimens. Here we report studies on the mechanism behind the HLA association.